Jacob Lewis was born in Macon county, Illinois.
He was married on the 21st of October in 1841 to Jane Cochran in St. Louis, Missouri. They lived in St. Clair County, Illinois until about 1860.
Jacob and Jane had the following children:
Elizabeth (b. 1843), John, Sarah, Catherine, Mary (b. 1848 m.Wm. Hignight, d. 1927), Jacob Jr., Malinda, Samuel, William, Charles, James, Cintha and Winnette (b. 1867)
His daughter Elizabeth married Samuel W. Whiteside in 1860 in Macon county, Illinois. His wife, Jane, died in 1868 in Macon County, Illinois.
Jacob married Harriet Little in St. Louis, Missouri, on 11 Oct. 1870. They lived in Turnback, Lawrence, Missouri, in 1880. One child, Charles was born in 1881 and later lived in Macon County, Illinois in the home of his sister, Elizabeth.